CRANE CHEMPHARMA & ENERGY · DIAPHRAGM VALVES
Saunders Bio-Block Manual Diaphragm Valves – Aseptic Weir Valves for Biopharm Applications
Saunders Bio-Block diaphragm valves for aseptic biopharm applications. Machined from solid 316L SS. FDA, USP, ASME BPE compliant. Available from PC

Overview
Saunders Bio-Block diaphragm valves represent the most advanced expression of aseptic diaphragm valve technology, specifically engineered for critical process applications in biopharmaceutical, API, and life science industries. These valves are machined from solid 316L stainless steel bar or billet to create tee configurations or multi-weir clusters with shared chambers, delivering superior process integrity.
The Bio-Block design eliminates the need for welded clusters, manifolds, and valve/fitting combinations by integrating multiple weirs into a single compact assembly. This results in reduced wetted surface area, optimum drainability, and minimal dead legs—critical factors for maintaining sterility and preventing contamination in aseptic processes.
Saunders invented and patented the original diaphragm valve concept, and the Bio-Block range continues this legacy of innovation with full compliance to global regulatory standards including FDA, USP, ASME BPE, and 3A certification.
Key Features
- Machined from solid 316L stainless steel (1.4435) for maximum integrity
- Zero dead leg configurations with optimum drainability
- Reduced wetted surface area compared to welded assemblies
- Multiple Bio-Block categories: Aseptic Weir (AW), Serial Weir (SW), Multi Weir (MW), Tank Weir (TW), and Zerostatic Weir (ZW)
- Traceable diaphragms including modified PTFE options
- Compact modular actuators (S360 & P345 series available)
- Full regulatory compliance for global biopharm applications
- Interactive web-based selection tools for valve configuration
Specifications
| Parameter | Value |
|---|---|
| Body Material | 316L Stainless Steel (1.4435) |
| Diaphragm Materials | PTFE, Modified PTFE, Elastomer |
| Compliance | FDA CFR 177.1550 (PTFE), 177.2600 (Elastomer) |
| Certifications | USP Class VI, <87>, <88>; 3A Certified |
| Standards | ASME BPE, BS EN 12266-1, ISO 9001 |
| Pressure Equipment | CE and PED 97/23/EC |
| Traceability | EN 10204 3.1 |
| Special Compliance | ADCF (Animal Derived Component Free), TUV-Merkblatt HPO |
Applications
Saunders Bio-Block valves are designed for critical aseptic applications across:
- Biopharmaceutical manufacturing – fermentation, chromatography, filtration, and filling lines - API (Active Pharmaceutical Ingredients) production - Sterile processing in vaccine and biologics manufacturing - Food and beverage – hygienic processing requiring zero dead leg designs - Cosmetics and consumer products – clean process environments - Biotech fermentation and cell culture systems
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